A venous blood sample requires 3 to 5 mL of blood to be collected from an athlete’s vein by a certified phlebotomist. Then, it is sent to a laboratory using temperature-controlled shipping. 

In comparison, a DBS sample is a small amount of blood, collected by a device that is operated by the athlete. A blood collection officer (BCO) is not required, and the sample is easier to ship to a laboratory.